Linking Aromatic Hydroxy Metabolic Functionalization of Drug Molecules to Structure and Pharmacologic Activity
نویسندگان
چکیده
منابع مشابه
Drug Design and Relationship of Functional Groups to Pharmacologic Activity
Medicinal chemistry is an interdisciplinary science at the intersection of organic chemistry, biochemistry (bioorganic chemistry), computational chemistry, pharmacology, pharmacognosy, molecular biology, and physical chemistry. This branch of chemistry is involved with the identifi cation, design, synthesis, and development of new drugs that are safe and suitable for therapeutic use in humans a...
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Figure 1: Directed aromatic functionalization methods. The title of this Thematic Series brings to the minds of most organic chemists the beautifully logical aromatic electrophilic substitution (SEAr) [1-5] and, to a lesser extent, nucleophilic aromatic substitution (SNAr) [2,6,7] reactions as taught to many generations of students in their first organic chemistry courses [8] (Figure 1). Being ...
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This article evaluates the effect of membrane active channel-forming polyene antibiotic (PA) of levorin and its alkyl derivatives on the muscle performance. The membrane channels of muscle cells are capable to transport ions of potassium, sodium, and calcium. In the period of an intensive muscle exercise, the necessity for organic substrates increases and these channels start to work with the g...
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ژورنال
عنوان ژورنال: Molecules
سال: 2018
ISSN: 1420-3049
DOI: 10.3390/molecules23092119